acetyl hexapeptide-8

Acetyl Hexapeptide-8 at a Glance

  • Also known as agireline and acetyl hexpeptide-3
  • Synthetically derived
  • Has water-binding abilities and skin-restoring properties
  • Is considered a neurotransmitter-inhibiting peptide

Acetyl Hexapeptide-8 Description

Acetyl hexapeptide-8 is a synthetically derived peptide that is used in a wide range of skin care and makeup products. Also known as agireline and acetyl hexapeptide-3, it, like all peptides, has water-binding properties and skin-restoring abilities. It is considered a neurotransmitter-inhibiting peptide, meaning it could have the ability to target expression wrinkles; however, that benefit has been overstated in certain cosmetics claims (it doesn’t replace in-office wrinkle-smoothing injectable procedures).

Studies on topical use of a moisturiser containing a 10% concentration of acetyl hexapeptide-8 have shown it does not penetrate beyond the uppermost layers of skin, even after several hours. That means it cannot affect factors in the underlying layers that lead to the formation of expression lines.

On the other hand, research has shown this peptide can penetrate further into skin if specific formulary steps are followed, including the type of emulsion (a higher water content showed greater penetration). As always, this demonstrates the importance of selecting well-formulated skin care products to add to your routine.

Acetyl Hexapeptide-8 References

Cosmetics, November 2020, Issue 7, Volume 4, page 91
La Clinica Terapeutica, November 2020, pages e539-e548
https://www.cir-safety.org/sites/default/files/AcetylHexapeptide-8.pdf
Cutaneous and Ocular Toxicology, March 2015, pages 46-52
European Journal of Pharmaceutical Sciences, February 2015, pages 27-35
Dermatologic Therapy, September-October 2007, issue 5, pages 343-349
International Journal of Cosmetic Science, October 2002, issue 5, pages 303-310

See peptides

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About the Experts

Paula Begoun is the best-selling author of 20 books about skincare and makeup. She is known worldwide as The Cosmetics Cop and creator of Paula’s Choice Skincare. Paula’s expertise has led to hundreds of appearances on national and international radio, print, and television including:

The Paula's Choice Research Team is dedicated to busting beauty myths and providing expert advice that solves your skincare frustrations so you can have the best skin of your life!