Pentapeptide-59 is a biomimetic (a synthetic ingredient that mimics the processes of a natural ingredient) peptide that contains the amino acids arginine, histidine, phenylalanine and valine. On skin, it has been shown to reduce signs of sensitisation, including visibly reducing redness. It also helps skin become less sensitive by neutralising signals in skin’s uppermost layers that would otherwise appear as signs of sensitivity.

In order to deliver this peptide to skin and keep it stable during use, it’s typically paired with emollient fatty acids such as shea butter or lecithin.

References for this information:

Clinical, Cosmetic, and Investigational Dermatology, January 2017, pages 11-16
Journal of Biochemistry, February 2017, pages 2,992–3,004
The Journal of Biological Chemistry, August 2008, pages 23,914-23,921

See peptides

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