25% Vitamin C + Glutathione Clinical Serum

25% Vitamin C + Glutathione Clinical Serum

Full | 30 ml / 1 fl. oz.
A$102.00
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25% Vitamin C + Glutathione Clinical Serum
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25% Vitamin C + Glutathione Clinical Serum

25% Vitamin C + Glutathione Clinical Serum

3.8
Rated 3.8 out of 5 stars
23
  • Age Prevention
  • Brightening
  • Fades Dark Spots

This clinical-level serum features highly stable 25% vitamin C to visibly improve uneven tone, radiance, elasticity & firmness without irritation.

  • Potent 25% vitamin C targets stubborn discolouration & sun damage
  • Glutathione minimises irritation & boosts skin’s antioxidant supply
  • GAP technology helps reduce oxidative stress & targets discolouration
  • Light, hydrating lotion for all skin types
A$102.00
Benefits

25% Vitamin C + Glutathione Clinical Serum is formulated with a highly stable blend of oil-and-water soluble vitamin C for optimal effectiveness. Glutathione + patented GAP technology (glutathione amino acid precursors) work to minimise irritation while amplifying antioxidant protection. This clinical-level formula helps sustain a natural level of glutathione & vitamin C within skin’s most uppermost layers for extended results, while reducing oxidative stress that triggers discolouration.

This lightweight vitamin C serum is clinically proven to improve uneven tone + discoloration while boosting radiance and brightening dullness. The pro-collagen formula visibly firms and improves the look of elasticity so you get advanced results—without irritation.

The packaging for the full-sized product is 25.9% recycled plastic (by weight).
How To Use

STEP 4: TARGET DISCOLOURATION

Apply onto face and neck. For optimal results, use AM and PM. For daytime, follow with SPF 30+.
Ingredients

Key Ingredients

  • Water/Aqua/Eau
  • Tetrahexyldecyl Ascorbate
  • Dimethicone
  • Glycerin
  • C9-12 Alkane
See All Ingredients
  • Ascorbyl Glucoside
  • Silica
  • Pyrus Malus (Apple) Fruit Extract
  • Hydrogenated Lecithin
  • Polyglyceryl-6 Polyricinoleate
  • Acrylates/C10-30 Alkyl Acrylate Crosspolymer
  • Xanthan Gum
  • Glutathione
  • Ergothioneine
  • Oryza Sativa (Rice) Bran Extract
  • Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer
  • Cetyl Alcohol
  • Caprylyl Glycol
  • Lysine Carboxymethyl Cysteinate
  • Coco-Caprylate/Caprate
  • Tocopherol
  • Sodium Citrate
  • Sodium Phytate
  • Hexylene Glycol
  • Ethylhexylglycerin
  • Urea
  • Mannitol
  • Caprylic/Capric Triglyceride
  • Sodium PCA
  • Rosmarinus Officinalis (Rosemary) Leaf Extract
  • Polysorbate 60
  • Sorbitan Isostearate
  • Trehalose
  • Ascorbic Acid
  • Glucose
  • Vanilla Planifolia Fruit Extract
  • Polyquaternium-51
  • Triacetin
  • Sodium Hyaluronate
  • Phenoxyethanol

Water (Aqua/Eau), Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus (Apple) Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Mannitol, Sodium Hydroxide, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Sodium Citrate, Xanthan Gum, Glutathione, Ergothioneine, Oryza Sativa (Rice) Bran Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco-Caprylate/Caprate, Tocopherol, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus (Sunflower) Extract, Urea, Caprylic/Capric Triglyceride, Sodium PCA, Rosmarinus Officinalis (Rosemary) Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Triacetin, Sodium Hyaluronate, Phenoxyethanol. il360v3

Paula's Choice is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
Research
  • Journal of Clinical and Aesthetic Dermatology, October 2023, pages 31-38
  • Experimental Gerontology, December 2022, pages 1–11
  • Antioxidants, August 2022, pages 1–18
  • International Journal of Cosmetic Science, December 2021, pages 691-702
  • Journal of Cosmetic Dermatology, September 2021, pages 2,349–2,359
  • Journal of Cosmetic Dermatology, December 2020, pages 3,251-3,257
  • International Journal of Cosmetic Science, August 2019, pages 378-386
  • Clinical Cosmetic and Investigative Dermatology, April 2017, pages 147-153; and October 2014, pages 267-274

FAQs

Who should use 25% Vitamin C + Glutathione Clinical Serum?

The 25% Vitamin C + Glutathione Clinical Serum is for all skin types, skin tones and ages. It is best for those showing numerous, more stubborn signs of sun damage, including dark discolourations, a dull complexion and moderate loss of firmness.

What is the difference between 25% Vitamin C + Glutathione Clinical Serum and C15 Super Booster?

The 25% Vitamin C + Glutathione Clinical Serum contains two vitamin C esters: 23% tetrahexyldecyl and ascorbate and 2% ascorbyl glucoside and is best suited for those with advanced concerns of discolourations, uneven skin tone and lack of firmness. The C15 Super Booster contains 15% pure ascorbic acid (vitamin C) and is a great option for everyone who wants a daily dose of vitamin C to help fortify skin and improve minor skin discolourations or dullness. It can be used alone or mixed into your favourite serum or non-SPF moisturiser.

Each product can be used on its own or in combination with one another (e.g., C15 during the day and 25% Vitamin C at night). Whether to use one or both will depend on your primary concerns and tolerance for these ingredients. We suggest experimenting to see what works best for your skin. As with all bioactive ingredients, start slowly and increase use as desired/needed.

Note: You may notice ascorbic acid listed at the bottom of the ingredient list for this product. The ascorbic acid is present in this formula in incidental amounts. As such, it does not have a brightening or antioxidant benefit to the skin. Instead, it’s part of the ascorbyl glucoside blend, used to help keep it stable and in the ideal pH range prior to being added to a cosmetic formula.

What is the difference between 25% Vitamin C + Glutathione Clinical Serum and the C25 Super Booster?

The 25% Vitamin C + Glutathione Clinical Serum is a comprehensive formula made for all-over facial use. With 23% tetrahexyldecyl ascorbate and 2% ascorbyl glucoside, it’s the most potent vitamin C product we offer and a great option for targeting stubborn concerns such as discolourations, uneven skin tone, fine lines and wrinkles.

The formula is water-based and contains several supporting ingredients, including potent antioxidants glutathione and ergothioneine. It also includes GAP technology, an amino acid blend proven to boost skin’s glutathione levels for enhanced activity of vitamin C and improved pollution defence (which helps further minimise the intensity of dark circles). While the C25 Super Booster was a great product, it was a spot treatment with a less robust formula that relied on 25% l-ascorbic acid to help fade discolourations.

Where should I store 25% Vitamin C + Glutathione Clinical Serum?

While there is research that supports it’s okay to keep water-based ascorbic acid (pure vitamin C) in the refrigerator to help prolong stability and delay in colour change, it’s important to note that this only applies to ascorbic acid in water. This does not apply to other ingredients or forms of vitamin C or when ascorbic acid is present without water. The only vitamin C product in the Paula’s Choice line we say is okay to store in the refrigerator is our C15 Super Booster, but even then, such storage is optional; room temperature is ideal. For other products, long-term exposure to cold temperatures can shorten the product’s lifespan, negatively impact stability and affect performance. The 25% Vitamin C + Glutathione Clinical Serum was deemed best stored at room temperature which is typically 68–72F (20– 22C). Refrigerating it to preserve the incidental amount of ascorbic acid would have a net negative effect on many of the other ingredients not meant for long-term cold storage. Note: The PAO (period after opening) for the 25% Vitamin C + Glutathione Clinical Serum is 12 months. For more information about refrigerating skin care products and our products’ shelf life, please visit our Help Centre.

Can you mix 25% Vitamin C + Glutathione Clinical Serum with C15 Super Booster or layer under C5 Super Boost Moisturizer?

Yes. In fact, you will see enhanced results and not have to worry about irritation since the forms of vitamin C in the 25% Vitamin C + Glutathione Clinical Serum do not have the same low pH requirements as pure ascorbic acid. You will get better free radical protection, better environmental defence and enhanced improvements in discolourations, wrinkles and loss of firmness. We recommend starting slow with multiple bioactive products to see how your skin responds and increasing use over time as needed/desired.

Can you mix 25% Vitamin C + Glutathione Clinical Serum with other bio-active products?

Yes, research has shown that vitamin C works well and can be used with other beneficial ingredients including niacinamide, retinol, peptides (except copper peptides, which Paula’s Choice does not use) and exfoliating acids. If you are currently using a prescription skincare product, we recommend consulting with your doctor for guidance on incorporating this serum into your routine. Here’s a few of our favourite combos: Vitamin C + Retinol: Retinol (in the form of retinyl palmitate) and vitamin C (ascorbic acid) are naturally present in skin, where they work to keep it healthy. Vitamin C and retinol can coexist and maintain their benefits in a single formula, or they may be formulated separately and layered. Vitamin C + Peptides: Vitamin C plays well with almost all peptides, working to protect skin and helping it repair damage. The only exception: copper peptides. These can oxidise vitamin C, making it less effective on skin. When using vitamin C and copper peptides in your routine, we recommend using one in the morning and the other at night to ensure maximum effectiveness. Vitamin C + Niacinamide: Together, vitamin C and niacinamide form a powerhouse combo that addresses uneven tone, wrinkles, loss of firmness and dullness. All skin types will see a complexion that becomes more radiant, smoother, more even and younger-looking when pairing the two ingredients. Vitamin C + AHA/BHA: The exfoliating action of AHA or BHA helps shed the buildup of skin cells that in turn allow vitamin C to penetrate past the skin’s surface. Using AHA/BHA prior to applying vitamin C enables it to be more effective.

Is 25% Vitamin C + Glutathione Clinical Serum good for rosacea or sensitive skin?

This may vary from person to person due to the amount of vitamin C in the formula which may prove too potent. We suggest patch testing this product on a small area to see how your skin responds. Vitamin C’s soothing action on the skin can be helpful for rosacea, as can the anti-redness benefits of glutathione and ergothioneine. If you’ve experienced sensitisation to higher amounts of vitamin C, we recommend you consider our C5 Super Booster Moisturizer which contains 5% vitamin C.

Is it safe to use 25% Vitamin C + Glutathione Clinical Serum during pregnancy or while breastfeeding?

The ingredients in the 25% Vitamin C + Glutathione Clinical Serum are generally considered safe to use during pregnancy or while breastfeeding. However, if you’re uncertain about starting a new anti-ageing product or a combination of ingredients, check with your physician and follow their advice. For additional information on the topic, be sure to review the following article: Which Skin Care Products Are Safe During Pregnancy?
3.8
Rated 3.8 out of 5 stars
Based on 23 reviews
65%would recommend this product
Total 5 star reviews: 12
Total 4 star reviews: 3
Total 3 star reviews: 4
Total 2 star reviews: 0
Total 1 star reviews: 4
Customers Talked About
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23 reviews
  • Hayley M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 weeks ago
    Worth Every Drop

    I’ve been so impressed with this Vitamin C serum. It leaves my skin looking fresh, glowing and full of life, and the texture is beautiful—it absorbs quickly without any greasy or sticky feeling. It fits perfectly into my morning routine and makes my skin feel healthy and nourished every day. It’s become a staple in my skincare collection and one I can’t imagine being without.

    Was this helpful?
  • Jen
    Flag of Australia
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    1 month ago
    Super product

    Yes very impressed with this. Definitely would purchase it

    Was this helpful?
  • Ren
    Flag of Australia
    Verified Buyer
    I recommend this product
    Pros Non-Greasy, Softens Skin, Lightweight, Soothes Skin
    Best Uses Fine Lines/Wrinkles, Enlarged Pores, Uneven Skin Tone
    Describe Yourself Beauty Conscious
    Rated 5 out of 5 stars
    1 month ago
    Excellent results

    I mix this with my moisturiser. A little goes a long way. So far I love it.

    Was this helpful?
  • Renee's M.
    Flag of Australia
    Verified Buyer
    I recommend this product
    Pros Non-Greasy, Softens Skin, Moisturises, Lightweight, Soothes Skin, Smells Great
    Best Uses Daily Use
    Describe Yourself Minimalist
    Rated 5 out of 5 stars
    1 month ago
    Lusciousl

    I tried this ad a sample. Loved it and ordered before the sample ran out. Not sure of how effective it is at this stage but it really is just lovely on your skin. Previous vit c I have used have been an oil based serum. This is a silken cream.

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  • Jess
    Flag of Australia
    Verified Buyer
    I do not recommend this product
    Pros Non-Greasy, Lightweight
    Cons Irritates Skin
    Describe Yourself Beauty Expert
    Rated 1 out of 5 stars
    1 month ago
    Be careful with this one

    This is not a reflection of the product for everyone. But please be careful, I used this once and my whole face has had a reaction, from my forehead all the way down to the base of my neck. I am puffy, swollen and red around the eyes and my whole face has a small sandpaper texture from a rash. This product is strong, and this reaction is from one use over the top of moisturiser which I did intentionally to create a barrier ti the skin. I've never had an issue with any PC products before and I love them. I am just warning anyone to be careful and spot test and wait 2 days as this reaction took 2 days to develop.

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    Paula's Choice - Australia
    1 month ago

    Hello! We’re sorry to hear this didn’t work out for your skin. This can occur for various reasons, as everyone’s skin responds differently. We encourage you to reach out to Client Services through the Help Centre or via email custservaustralia@paulaschoice.com for assistance and alternate recommendations if needed. We hope this helps. – PC